Increased expression of dopamine receptors on lymphocytes in Parkinson's disease
Identifieur interne : 004D26 ( Main/Exploration ); précédent : 004D25; suivant : 004D27Increased expression of dopamine receptors on lymphocytes in Parkinson's disease
Auteurs : Piero Barbanti ; Giovanni Fabbrini ; Alberto Ricci ; Rosanna Cerbo ; Elena Bronzetti ; Brunella Caronti ; Caterina Calderaro ; Laura Felici ; Fabrizio Stocchi [Italie] ; Giuseppe Meco ; Francesco Amenta [Italie] ; Gian Luigi LenziSource :
- Movement Disorders [ 0885-3185 ] ; 1999-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Binding, Competitive (physiology), Brain (pathology), Cell Count, Dopamine Agonists (pharmacokinetics), Dopamine receptor, Exploration, Female, Gene expression, Human, Humans, Levodopa (therapeutic use), Lymphocyte, Lymphocytes (metabolism), Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (metabolism), Parkinson disease, Parkinson's disease, Radioligand Assay, Receptors, Dopamine (metabolism), Sensitivity and Specificity, Treatment Outcome.
- MESH :
- chemical , metabolism : Receptors, Dopamine.
- chemical , pharmacokinetics : Dopamine Agonists.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- metabolism : Lymphocytes, Parkinson Disease.
- pathology : Brain.
- physiology : Binding, Competitive.
- Aged, Cell Count, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Radioligand Assay, Sensitivity and Specificity, Treatment Outcome.
Abstract
Dopamine D1‐like and D2‐like receptors on peripheral blood lymphocytes (PBL) were assayed in 50 de novo patients with idiopathic Parkinson's disease (PD), in 36 neurologic control subjects (multiple‐system atrophy, n = 16; essential tremor, n = 10; other neurodegenerative diseases, n = 10), and in 26 healthy control subjects by radioligand binding assay techniques using [3H]SCH 23390 and [3H]7OH‐DPAT as ligands. Patients with PD revealed a higher density (Bmax) of dopamine D1‐like (p <0.001) and D2‐like (p <0.00001) receptors on PBL than either neurologic or healthy control subjects, whereas no differences in Bmax were observed among patients affected by other neurologic diseases and healthy control subjects. The affinity (Kd) of both radioligands was similar in the groups investigated. The pharmacologic profile of [3H]SCH 23390 and [3H]7OH‐DPAT binding was consistent with the labeling of dopamine D5 and D3 receptor subtypes, respectively. Twenty‐five of the 50 patients with PD were retested after 3 months of therapy with levodopa or bromocriptine. Both treatments reduced the density of D1‐like (p <0.001) and D2‐like (p <0.001) receptors on PBL to values comparable to those of control subjects. The increased density of D1‐like and D2‐like receptors on PBL in de novo PD patients may represent an upregulation mechanism resulting from the diffuse impairment of the dopaminergic system in PD.
Url:
DOI: 10.1002/1531-8257(199909)14:5<764::AID-MDS1008>3.0.CO;2-W
Affiliations:
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Le document en format XML
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<term>Brain (pathology)</term>
<term>Cell Count</term>
<term>Dopamine Agonists (pharmacokinetics)</term>
<term>Dopamine receptor</term>
<term>Exploration</term>
<term>Female</term>
<term>Gene expression</term>
<term>Human</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Lymphocyte</term>
<term>Lymphocytes (metabolism)</term>
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<term>Middle Aged</term>
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<term>Parkinson's disease</term>
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<term>Sensitivity and Specificity</term>
<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en">Dopamine D1‐like and D2‐like receptors on peripheral blood lymphocytes (PBL) were assayed in 50 de novo patients with idiopathic Parkinson's disease (PD), in 36 neurologic control subjects (multiple‐system atrophy, n = 16; essential tremor, n = 10; other neurodegenerative diseases, n = 10), and in 26 healthy control subjects by radioligand binding assay techniques using [3H]SCH 23390 and [3H]7OH‐DPAT as ligands. Patients with PD revealed a higher density (Bmax) of dopamine D1‐like (p <0.001) and D2‐like (p <0.00001) receptors on PBL than either neurologic or healthy control subjects, whereas no differences in Bmax were observed among patients affected by other neurologic diseases and healthy control subjects. The affinity (Kd) of both radioligands was similar in the groups investigated. The pharmacologic profile of [3H]SCH 23390 and [3H]7OH‐DPAT binding was consistent with the labeling of dopamine D5 and D3 receptor subtypes, respectively. Twenty‐five of the 50 patients with PD were retested after 3 months of therapy with levodopa or bromocriptine. Both treatments reduced the density of D1‐like (p <0.001) and D2‐like (p <0.001) receptors on PBL to values comparable to those of control subjects. The increased density of D1‐like and D2‐like receptors on PBL in de novo PD patients may represent an upregulation mechanism resulting from the diffuse impairment of the dopaminergic system in PD.</div>
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<affiliations><list><country><li>Italie</li>
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<tree><noCountry><name sortKey="Barbanti, Piero" sort="Barbanti, Piero" uniqKey="Barbanti P" first="Piero" last="Barbanti">Piero Barbanti</name>
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<name sortKey="Calderaro, Caterina" sort="Calderaro, Caterina" uniqKey="Calderaro C" first="Caterina" last="Calderaro">Caterina Calderaro</name>
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<name sortKey="Felici, Laura" sort="Felici, Laura" uniqKey="Felici L" first="Laura" last="Felici">Laura Felici</name>
<name sortKey="Lenzi, Gian Luigi" sort="Lenzi, Gian Luigi" uniqKey="Lenzi G" first="Gian Luigi" last="Lenzi">Gian Luigi Lenzi</name>
<name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name>
<name sortKey="Ricci, Alberto" sort="Ricci, Alberto" uniqKey="Ricci A" first="Alberto" last="Ricci">Alberto Ricci</name>
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<country name="Italie"><noRegion><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name>
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